Cadence to become one of Genesis Mission Consortium’s partners to accelerate AI-driven science
Cadence has joined the Genesis Mission Consortium, the US Department of Energy’s public-private partnership that uses AI to speed up scientific discovery, strengthen national security, and advance energy innovation. The company will contribute AI-enabled design and simulation technology and technical expertise, working with DOE National Laboratories on priorities including advanced microelectronics, quantum and superconducting systems, data center energy efficiency, and AI-driven scientific workflows.
The consortium was launched by Executive Order in November 2025 and is led by DOE Under Secretary for Science Dr. Darío Gil. Its goal is to double the productivity and impact of American science and engineering within a decade by connecting the country’s leading supercomputers, AI systems, experimental facilities, and unique datasets across the 17 National Laboratories. Beyond DOE and the labs, it brings in other federal agencies, industry, and academia to tackle challenges in advanced manufacturing, biotechnology, materials science, nuclear energy, quantum information science, and semiconductors.
Tom Beckley, senior vice president of Strategic Technology Programs at Cadence, said the company has long believed AI-driven design and physics-based simulation will reshape how critical systems are built, from advanced semiconductors to AI factories and physical AI. He described joining as a commitment to put Cadence’s AI-enabled EDA and SDA technologies and engineering expertise in service of American scientific leadership, working alongside the labs, consortium partners, and the research community to speed up discoveries that support US competitiveness and energy security.
The move builds on existing collaborations with DOE and DOE/NNSA labs, including Sandia, Fermi National Accelerator Laboratory, Oak Ridge, Lawrence Livermore, NASA Ames Research Center, Argonne, and Brookhaven. Cadence’s AI-enabled tools already support modeling, simulation, verification, and large-scale engineering analysis aligned with DOE science, energy, and national security priorities. Dr. Jeffrey Vetter, corporate fellow and section head of Advanced Computing Systems Research at Oak Ridge, said the Genesis Mission is a chance to accelerate discovery through AI, high-performance computing, and advanced design tools, and that working with Cadence will bring advanced engineering capabilities into research workflows.
Cadence says its participation advances a strategy that combines agentic AI, physics-based simulation, digital twin technology, and HPC across semiconductor design, physical AI systems, and AI factories, and it plans to extend those capabilities to the DOE research community in four ways. The first is subject-matter expertise, helping scope and pilot AI model development and validation, data standards, and HPC. The second is targeted access to its AI-enabled EDA, system design and analysis, multiphysics simulation, digital twin, advanced packaging, and 3D-IC workflows for pilots and demonstrations. The third is workflow integration, supporting the integration of Cadence workflows with laboratory HPC environments, including reproducible packaging and “AI performance” benchmarking. The fourth is workforce development, working with the labs and academic partners on training and curriculum for AI-enabled engineering.
